Vol.1, No 3, 1998 pp. 9 -15
UDC:582.824
CONTRIBUTION TO INVESTIGATION OF ST. JOHN'S WORT HERB EXTRACTS HYPERICUM PERFORATUM L. SSP. ANGUSTIFOLIUM, OBTAINED BY HIGH PRESSURE EXTRACTION WITH CO2
Andrija Šmelcerović1, Siniša Đorđević1, Branislav Gudžić2,
Milovan Dimić2, Žika Lepojević3
1 Faculty of Technology Leskovac, Bulevar oslobođenja 124, 16000 Leskovac, Yugoslavia
2 DD "Zdravlje" Pharmaceutical & Chemical Industry, Vlajkova 199, 16000 Leskovac, Yugoslavia
3 Faculty of Technology Novi Sad, Cara Lazara 1, 21000 Novi Sad, Yugoslavia
Abstract. The extracts of St. John's wort Hypericum perforatum L .ssp. angustifolium from the new locality, Sobina, (the surroundings of Vranje, South Serbia, Yugoslavia) obtained by high pressure extraction with CO2, exert antimicrobial action, where the extract obtained under higher pressure exerted stronger action. The extracts exerted the best antimicrobial action on Candida albicans fungi. The practical application of HPE (High Pressure Extraction) for obtaining extracts of St. John's wort herb suitable for producing parapharmaceutical preparations will depend on techno-economic analysis, which will compare them, in terms of quality and price, with the extracts obtained by classic procedures.
PRILOG ISPITIVANJU EKSTRAKATA KANTARIONA HYPERICUM PERFORATUM L. SSP. ANGUSTIFOLIUM DOBIJENIH EKSTRAKCIJOM SA CO2 POD VISOKIM PRITISKOM
Ekstrakti kantariona Hypericum perforatum L. ssp. angustifolium sa novog lokaliteta Sobina (okolina Vranja, južna Srbija, Jugoslavija), dobijeni ekstrakcijom sa CO2 pod visokim pritiskom, pokazuju antimikrobno dejstvo, s' tim što ekstrakt dobijen pod višim pritiskom pokazuje jače dejstvo. Najbolje antimikrobno dejstvo ekstrakti pokazuju na gljivici Candida albicans. Praktična primena HPE (High Pressure Extraction), za dobijanje ekstrakata kantariona pogodnih za izradu parafarmaceutskih preparata zavisiće od tehno-ekonomske analize, u kojoj će se uporediti, u pogledu kvaliteta i cene, sa ekstraktima dobijenim klasičnim postupcima.