Vol. 11, No 1, 2013 pp. 101 - 107
DOI 10.2298/FUPCT1301101D
UDC 543.429.23 : 547.1-32-304.2 + 547.814.1

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¹H AND ¹³C NMR SPECTRAL ASSIGNMENTS OF AN AMINO ACID-COUMARIN HYBRID
Vidoslav Dekić¹, Biljana Dekić¹, Niko Radulović^2
1Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220 Kosovska Mitrovica, Serbia
²Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia
E-mail: nikoradulovic@yahoo.com

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Abstract. Synthesis and detailed spectral analysis of a new 4-substituted coumarin-amino acid derivate are presented in this paper. A new glycine derivate of (3-nitro-2-oxo-2H-chromen-4-yl)amino]acetate was prepared by condensation of 4-chloro-3-nitrocoumarin and ethyl glycinate hydrochloride. The complete assignment of 1H and 13C NMR chemical shifts of the synthesized compound was carried out by the aid of a combination of 1D (1H and 13C NMR) and 2D (1H-1H-COSY, NOESY, HSQC and HMBC) NMR experiments.
Key words: 4-chloro-3-nitrocoumarin, glycine, synthesis, spectral analysis, ¹H NMR, ¹³C NMR, 2D NMR

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ASIGNACIJA ¹H I ¹³C NMR SPEKTARA AMINOKISELINSKOG DERIVATA KUMARINA U ovom radu su opisani sinteza i spektralna analiza novog aminokiselinskog derivata kumarina. Glicinski derivat kumarina [(3-nitro-2-oxo-2H-chromen-4-yl)amino]acetate dobijen je kondenzovanjem 3-hlor-4-nitrokumarina i etil-glicinat hidrohlorida. Kompletna asignacija signala u 1H i 13C NMR spektrima sintetisanog jedinjenja izvršena je kombinovanjem 1H i 13C NMR sa 1H-1H- COSY, NOESY, HSQC i HMBC eksperimentima.
Ključne reči: 4-hlor-3-nitrokumarin, glicin, sinteza, spektralna analiza, ¹H NMR, ¹³C NMR, 2D NMR