Vol. 7, No 1, 2009 pp. 73 - 80
DOI 10.2298/FUPCT0901073S
UDC 66.091.3
SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL
ACTIVITY OF
COBALT METAL COMPLEX AGAINST MULTI DRUG RESISTANT
BACTERIAL AND FUNGAL PATHOGENS
Subhasish Saha1, Dharumadurai Dhanasekaran1,
Sarvanan Chandraleka2, Annamalai Panneerselvam2
1Department of Microbiology, Bharathidasan
University, Trichirapalli.620 024.
2P.G. & Research Department of
Botany & Microbiology, A.V.V.M. Sri Pushpam College, (Autonomous),
Poondi, 613 503 Thanjavur District, Tamil Nadu. India
Abstract. Cobalt complex with histidine ligand was synthesized and
physico-chemically characterized by solubility testing, melting point,
UV-spectra and FTIR. The synthesized metal complex was evaluated for in-vitro
antibacterial and antifungal activity against the multidrug resistant pathogens,
such as Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, E. coli,
Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus
flavus and Candida albicans. The metal complex showed the significant antibacterial
and antifungal activity comparison with commercial antibiotics. Further
work can be extended through In-silico docking of this metal complex and
bacterial, fungal genome which can be given a better idea about genome
metal interaction in molecular level.
SINTEZA I KARAKTERIZACIJA KOMPLEKSA JONA
KOBALTA I HISTIDINA,
KAO I NJEGOVA MIKROBIOLOSKA AKTIVNOST PROTIV
VISESTRUKO OTPORNIH PATOGENIH SOJEVA BAKTERIJA I GLJIVICA
Ostvarena je sinteza kompleksa jona kobalta i histidina kao liganda koji
je fiziko-hemijski okarakterisan (odredena je njegova rastvorljivost, tacka
topljenja, a i snimljeni su njegovi UV i IC spektri). In vitro antibakterijska
i antifungalna aktivnost sintetisanog kompleksa je testirana na visestruko
otpornim patogenim sojevima, kao sto su: Pseudomonas aeruginosa, Vibrio
cholerae, Salmonella typhi, Escherichia coli, Klebsiella pneumonia, Staphylococcus
aureus, Aspergillus niger, Aspergillus flavus i Candida albicans. Kompleks
je pokazao znacajnu antibakterijsku i antifungalnu aktivnost u poredenju
sa komercijalnim antibioticima koji su paralelno testirani sa njim. Dalja
istrazivanja u smislu in silico ekperimenata bi pruzila informacije o interakciji
ovog kompleksa kobalta sa genomom bakterija i gljivica na molekulskom nivou.
