Vol.2, No 4, 2002 pp. 235 - 243
UDC 539.1
RADIONUCLIDIC GENERATORS FOR
THE PRODUCTION OF TECHNETIUM-99M AND RHENIUM-188
Jurij Vučina, Dragoljub Lukić
Vinča Institute of Nuclear Sciences, Laboratory for Radioisotopes 11001
Belgrade, P.O.Box 522 Serbia and Montenegro
Abstract. The paper deals with production and application of open
radioactive sources in modern diagnostic and therapeutic nuclear medicine.
In principle, besides adequate physical, chemical and biological properties
a reliable route for the routine production of both radionuclide and radiopharmaceutical
should be on disposal. The favorite route are radionuclidic generators
as they enable simple production of shorter-lived radionuclides at relatively
low costs. The main radionuclide in diagnosis is technetium-99m. Its advantages
are favorable nuclear properties, availability of large activities of high
quality 99mTc at reasonable prices by using (n,f)99Mo/99mTc generators
and versatile chemistry. It is used in the investigation of practically
all organs and tissues in the human body. Among the beta-emitters the radionuclides
of rhenium have been recently proposed as suitable candidates for therapeutic
applications. The most important is 188Re which is obtained from 188W/188Re
generator. Some of the important radiopharmaceuticals labeled with rhenium
radionuclides used for certain specific indications are also shown. The
activities performed in the Laboratory for Radioisotopes (Vinča Institute
of Nuclear Sciences) are also enclosed.
Key words: technetium-99m, rhenium-186, rhenium-188, diagnosis,
therapy, nuclear medicine
RADIONUKLIDNI GENERATORI ZA DOBIJANJE
TEHNECIJUMA-99M I RENIJUMA-188
Prikazani su neki od najvažnijih aspekata proizvodnje i primene otvorenih
izvora radioaktivnog zračenja u dijagnostičkoj i terapijskoj nuklearnoj
medicini. Pored fizičkih, bitne su i hemijske i biohemijske osobine datog
radionuklida odnosno radiofarmaceutika. Uslov za redovnu primenu su i dostupnost,
kvalitet i cena. Radionuklidni generatori predstavljaju vrlo pogodan izvor
dobijanja radionuklida kraćih vremena poluraspada. Najvažniji dijagnostički
radionuklid je 99mTc. Odlične fizičke osobine, visok kvalitet i laka dostupnost
po prihvatljivim cenama korišćenjem molibden-99/tehnecijum-99m generatora
i razvijena hemija doveli su do toga da ovaj radionuklid postane praktično
nezamenjiv u ispitivanju skoro svih organa i tkiva u ljudskom organizmu.
Dati su savremeni trendovi u razvoju proizvodnje radionuklida i radiofarmaceutika
za primenu u terapijske svrhe. Prikazani su načini dobijanja radionuklida
renijuma (186Re i 188Re) sa posebnim naglaskom na 188W/188Re generatoru.
Dati su hemijski oblici i indikacije za primenu nekih radioaktivnih lekova
obeleženih ovim radionuklidima. Prikazana su istraživanja sprovedena u
Laboratoriji za radioizotope (Institut za nuklearne nauke ŤVinčať).
Ključne reči: tehnecijum-99m, renijum-186, renijum-188, nuklearna
medicina, dijagnostika, terapija.
