Vol.6, No 1, 1999 pp. 73 - 77
UC 616.074
STEARIC FATTY ACID IN ADIPOSE TISSUE IN
SOME PATHOLOGIC CONDITIONS
UNITED WITH PRETERM ATHEROSCLEROSIS
Lazar Lepšanović1, Ljiljana Lepšanović2, Ištvan Verešbaranji3,
Tatjana Ivković-Lazar1, Mirjana Djerić2, Edita
Stokić1
1Department of Endocrinology, Diabetes and Metabolic Disease
2Department of Pathophysiology and Laboratory Diagnostics
3Faculty of Medicine and Institute of Field and Vegetable
Crops, University of Novi Sad, Yugoslavia
Summary. In the paper the findings of investigations of the percentage
of content of stearic fatty acids in adipose tissue from 250 persons are
presented, containing different disturbances and having very often as consequence
a preterm development of atherosclerosis. The results are compared with
a control group (n = 93) of metabolic healthy and normally nourished persons.
The method of gas-liquid chromatography is used. Except for persons with
an phenotype picture of hyperlipoproteinemia type IIa, in all persons (obese,
NIDDM, sudden death from myocardial infarction, other types of hyperlipoproteinemia)
significant lower values of stearic fatty acids compared to the control
group (p<0.005-0.001) are determined and a significant connection of
its decrease with the degree of nourishedness. (r = 0.662, p<0.001)
in obese persons is also discovered. In opposition to that, undernourished
persons had some higher value of stearic fat acids statistically insignificant.
The results are completely in accordance with our earlier findings in separate
lipid fractions in serum and in serum in general.
The fact that some other authors who invesigated the problem have come
to identical results points to the conclusion that our investigations represent
the confirmation of a new knowledge about the antiatherogenic effect of
the fatty acids in contrast with other long chain saturated fatty acids.
No doubt, these findings have certain implications on treatment of patients
as well.
Key words: Fatty acid composition of adipose tissue, stearic
acid, atherosclerosis, coronary heart disease
STEARINSKA MASNA KISELINA U MASNOM TKIVU
OSOBA S NEKIM PATOLOŠKIM STANJIMA UDRUŽENIM S PRERANOM ATEROSKLEROZOM
Kratak sadržaj: U radu se iznose rezultati istraživanja procentnog
sadržaja stearinske masne kiseline u masnom tkivu ispitanika (n=250) s
različitim poremećajima u kojih vrlo često dolazi do preranog razvitka
ateroskleroze. Nalazi su uporedjeni s kontrolnom grupom (n=93) metabolički
zdravih i normalno uhranjenih osoba. Korišćena je metoda gasnotečne hromatografije.
S izuzetkom osoba s fenotipskom slikom hiperlipoproteinemije tipa IIa,
u svih ispitanika (gojazni, NIDDM, iznenada umrli od infarkta miokarda,
drugi tipovi hiperlipoproteinemija) konstatovane su signifikantno niže
vrednosti stearinske masne kiseline nego u kontrolnoj grupi (p<0,005-0,001),
a u gojaznih i signifikantna povezanost njenog smanjenja sa stepenom uhranjenosti
(r=0,662; p<0,001). Suprotno ovome, pothranjene osobe imaju čak nešto
više vrednosti stearinske masne kiseline, ali to povećanje nije statistički
značajno. Ovi nalazi potpuno su u skladu s rezultatima naših ranijih ispitivanja
u pojedinim lipidskim frakcijama seruma i u serumu kao celini. Činjenica
da su do identičnih rezultata došli i drugi retki autori koji su proučavali
ovaj problem, upućuju na zaključak da naša istraživanja predstavljaju potvrdu
novih saznanja o antiaterogenom efektu ove masne kiseline za razliku od
drugih zasićenih masnih kiselina dugog lanca. Nesumnjivo da ova saznanja
imaju odredjene implikacije i na terapijskom planu.
Ključne reči: Masnokiselinski sastav masnog tkiva, stearinska
kiselina, ateroskleroza, koronarna bolest
