Vol.5, No 1, 1998 pp. 40 - 43
UDC: 618.38
URINARY ENZYMES EXCRETION AFTER ACUTE
ADMINISTRATION OF PARACETAMOL
IN PATIENTS WITH KIDNEY DISEASE
Marina Mitić-Zlatković, Rade Čukuranović, Vladisav Stefanović
Institute of Nephrology and Hemodialysis, Faculty of Medicine, Niš,
Yugoslavia
Summary. The effect of paracetamol, commonly used as analgesic drug,
upon excretion of some enzymes, markers of kidney damage, was investigated.
Patients with Balkan endemic nephropathy and glomerulonephritis, having
kidney vulnerable to toxic drugs, were enrolled in the study. Timed urine
specimens were collected: before drug administration, and in 3h periods
for 24 h after an oral dose of 2 g of paracetamol.
Excretion of APN activity related to mmol creatinine before paracetamol
treatment was significantly higher in patients with glomerulonephritis
than in healthy persons from the city or village, and from BEN patients.
Urinary excretion of DPP IV and GGT was significantly increased
in patients with glomerulonephritis, BEN, and in clinically healthy inhabitants
of the endemic villages compared to healthy adults from the city. After
paracetamol administration urinary excretion of APN, DPP IV and GGT did
not change significantly in any group studied.
This study has shown that urinary excretion of APN, DPP IV and GGT,
as markers of kidney brush border damage, did not change after 2 g of paracetamol
taken orally.
Key words: Paracetamol, Balkan endemic nephropathy, glomerulonephritis,
aminopeptidase N, dipeptidylpeptidase IV, gamma-glutamyltranspeptidase
IZLUČIVANJE ENZIMA URINOM NAKON
UZIMANJA PARACETAMOLA
KOD OSOBA SA BUBREŽNOM BOLEŠĆU
Ispitivan je efekat paracetamola, leka koji se koristi kao analgetik,
na izlučivanje nekih enzima, markera oštećenja bubrega. U ovoj studiji
obradjeni su bolesnici sa Balkanskom endemskom nefropatijom i glomerulonefritisom
čiji su bubrezi osetljivi na toksično dejstvo lekova. Sakupljani su sledeći
uzorci urina: pre uzimanja leka, i u intervalima od 3 sata za period od
24 sata nakon oralnog uzimanja 2 grama paracetamola.
Aktivnost APN u urinu po mmol kreatinina, pre tretiranja paracetamolom
je značajno veća u bolesnika sa glomerulonefritisom nego u zdravih osoba
iz grada i seoskog područja, kao i obolelih od BEN. Izlučivanje DPP
IV i GGT urinom prema mmol kreatinina značajno je povećano u bolesnika
sa glomerulonefritisom, BEN i u klinički zdravih ispitanika iz endemskih
sela u odnosu na zdrave osobe iz grada. Tretman paracetamolom ne daje nikakve
značajne razlike u izlučivanju enzima APN, DPP IV i GGT kod ispitivanih
grupa.
U ovoj studiji je ustanovljeno da nakon uzimanja 2 grama paracetamola
ne dolazi do promena aktivnosti enzima APN, DPP IV i GGT, kao markera oštećenja
četkastog pokrova bubrega.
Ključne reči: Paracetamol, Balkanska endemska nefropatija, glomerulonefritis,
aminopeptidaza N, dipeptidilpeptidaza IV, gama-glutamiltranspeptidaza
