Vol.15, No 1, 2008 pp. 24 - 27
UC 613.888:[618.14:612.15]
COLOR DOPPLER MEASUREMENTS OF UTERINE
ARCUATE BLOOD FLOW IN PATIENTS ON ORAL CONTRACEPTION
Kutlešić Ranko, Milosavljević Mileva, Vukomanović Predrag, Stefanović
Milan, Vučetić Dragana
Clinic of Gynecology and Obstetrics Niš
E-mail: kutlesicr@medianis.net
Summary. The aim of this study is to determine if there are differences
in vascular impedance of uterine arcuate arteries between spontaneous ovulatory
cycles and cycles in which monophasic combination containing 0,03 mg ethynilestradiol
and 2 mg dienogest was administered for contraception. Twenty two patients
were included: 11 patients on oral contraceptives, 11 patients with spontaneous
ovulatory cycles. Ultrasound examinations, using 7 MHz endovaginal transducer
with color Doppler imaging and pulsed spectral analysis, were performed
after 15 days of therapy in patients on oral contraceptives and in periovulatory
period in the second group. The mean ages were similar – 23 ± 5.65 years
in the group on oral contraceptive and 28 ± 5.09 years in the group with
spontaneous ovulatory cycles (p = 0.20465). Pulsatily index was lower in
the group with spontaneous ovulatory cycles (0.98±0.255 vs. 2.38 ± 0.127,
p = 0.00038). Resistance index was lower in the group with spontaneous
ovulatory cycles (0.59 ± 0,054 vs. 0,795 ± 0,007, p = 0,000145), also
as S/D ratio (2.59 ± 0.247 vs. 4,9 ± 0.14, p = 0.000182). There were
no significant differences in peak systolic velocity between group on oral
contraception and spontaneous ovulatory cycles (17 ± 9.89 cm/sec. vs.
8.5 ± 3.33 cm/sec, p = 0.21728). Vascular impedance of uterine arcuate
arteries was higher in patients on oral contraception containing 0.03 mg
ethynilestradiol and 2 mg dienogest than in patients with spontaneous ovulatory
cycles.
Key words: Color doppler, oral
contraception, dienogest
KOLOR DOPPLER MERENJA PROTOKA KRVI KROZ
ARTERIJE ARKUATE UTERUSA U PACIJENTKINJA NA ORALNOJ KONTRACEPCIJI
Kratak sadržaj: Cilj ovog ispitivanja je da se odredi da li postoje
razlike u vaskularnoj impedanci arteriola arkuata uterusa izmedju spontanih
ovulatornih ciklusa i ciklusa u kojima je korištena monofazna kombinacija,
koja sadrži 0,03 mg etinilestradiola i 2 mg dienogesta, data u svrhu kontracepcije.
Dvadeset dve pacijentkinje su uključene u ovo ispitivanje: 11 na oralnoj
kontracepciji, 11 sa spontanim ovulatornim ciklusima. Ultrazvučni pregledi,
uz korištenje endovaginalne sonde od 7 MHz sa kolor Doppler prikazom i
pulsnog Dopplera, su sprovedeni posle 15 dana terapije u pacijentkinja
na oralnoj kontracepciji i u periovulatornom periodu u drugoj grupi. Izmedju
ove dve grupe nije bilo razlika u životnom dobu - 23±5,65 godina u grupi
na oralnoj kontracepciji i 28 ± 5,09 godina u grupi sa spontanim ovulatornim
ciklusima (p = 0,20465). Pulsatilni indeks je bio niži u grupi sa spontanim
ovulatornim ciklusima (0,98±0,255 prema 2,38 ± 0,127, p=0,00038). Indeks
rezistence je bio niži u grupi sa spontanim ovulatornim ciklusima (0,59
± 0,054 prema 0,795 ± 0,007, p=0,000145), takodje i S/D odnos (2,59±0,247
prema 4,9±0,14, p=0,000182). Nije bilo signifikantne razlike u maksimalnoj
brzini protoka u sistoli izmedju grupe na oralnoj kontracepciji i spontanih
ovulatornih ciklusa (17±9,89 cm/sec prema 8,5±3,33 cm/sec, p=0,21728).
Vaskularna impedanca uterusnih arterija arkuata je viša u pacijentkinja
na oralnoj kontracepciji koja sadrži 0,03 mg etinilestradiola i 2 mg dienogesta,
nego u pacijentkinja sa spontanim ovulatornim ciklusima.
Ključne reči: Kolor Dopler,
oralna kontracepcija. dienogest
