Vol.13, No 3, 2006 pp. 168 - 171
UC 618.177-073.43
CHANGE DYNAMICS OF DOMINANT AND NONDOMINANT
UTERINE ARTERY AND OVARIAN ARTERY IN STIMULATED CYCLES
IN INFERTILE WOMEN
Vekoslav Lilić, Aleksandra Tubić-Pavlović, Goran Lilić
Clinic of Gynecology and Obstetrics, Clinical Center Niš
Summary. Our aim was to investigate hemodynamic changes in the uterine artery, its branches and in ovarian artery, and to establish their significance in infertility investigation. In the prospective study in the period January-December 2005, 90 infertile women in their generative age were monitored by color Doppler method in the same number of cycles. Hemodynamic changes in the uterine and ovarian artery at the dominant and non dominant side were monitored on certain cycle days (XI, XIV and XX cycle days) according to the following parameters: Pi (pulsatile index), Ri (resistance index) and Vmax (maximal flow velocity). The quality of endometrial receptivity was determined based on the EPDA (Endometrial Power Doppler Area). With Mann Whitney U test it was established that there is a significant difference in the obtained hemodynamic parameters among the dominant and non dominant ovarian artery on day XI of the cycle (Pi-3.17, Ri-2.90 and 4.51, Vmax-2.81) in all three groups of the examinees, and on day XIV, Vmax was markedly higher in pregnant women (Vmax-2.49) and in the group of women with spontaneous cycles (Vmax-2.89). Statistically significant difference among the dominant and non dominant uterine artery was found only in pregnant women on XX cycle day (Pi-2.05, Ri-2.49, Vmax 2.89) for each of those three parameters. The frequency of ovulation was higher on the right side (70%) compared to the left side (30%) of blood vessels. The measurement of hemodynamic changes in uterine and ovarian arteries can be of use to the doctor in infertility studies, in the correction of ovulation inducers and in pregnancy prediction.
Key words: Infertility, color Doppler, hemodynamic parameters
DINAMIKA PROMENA DOMINANTNE I NEDOMINANTNE ARTERIJE UTERINE
I ARTERIIJE OVARIKE U STIMULISANIM CIKLUSIMA INFERTILNIH ŽENA

Kratak sadržaj: Cilj rada je bio da se ispitaju hemodinamske promene u arteriji uterini, njenim granama, kao i arteriji ovarici i utvrdi njihov značaj u ispitivanju infertiliteta. U prospektivnoj  studiji u periodu januar - decembar 2005. godine, metodom color doplera, praćeno je 90 infertilnih žena, u isto toliko ciklusa, u generativnoj dobi. Bile su podeljene u tri grupe. Praćene su hemodinamske promene arterije uterine i arterije ovarike dominantne i nedominantne strane po danima ciklusa (XI, XIV i XX dan ciklusa), parametrima: Pi (pulsatilni indeks), Ri (indeks otpora) i V max. (maksimalna brzina protoka). Kvalitet receptivnosti endomerijuma odredjivan je na osnovu pojave EPDA (Endometrial Power Area). Mann Whitney U Testom je utvrdjeno da postoji stastički značajna razlika u dobijenim vrednostima ispitivanih hemodinamskih parametara između dominantne i nedominantne arterije ovarike XI dana ciklusa (Pi-3,17, Ri-2,90 i 4,51, Vmax-2,81) kod sve tri grupe pacijentkinja, da bi već XIV dana V max bila značajno viša u grupi gravidnih žena (Vmax-2,49) ali i u grupi žena sa spontanim ciklusima (Vmax-2,89). Stistički značajna razlika između dominantne i nedominantne arterije uterine postoji samo kod grupe gravidnih žena XX dana ciklusa (Pi-2,05, Ri-2,49, Vmax-2,89) za sva tri parametra. Učestalost ovulacija je veća desno (70%) u odnosu na levu stranu (30%) krvnih sudova. Merenje hemodinamskih promena u arteriji uterini i arteriji ovarici može koristiti lekaru u ispitivanju infertiliteta, u korekciji induktora ovulacije, kao i u predikciji trudnoće.
Ključne reči: infertilitet, color Doppler, hemodinamski parametri