Vol.13, No 2, 2006 pp. 98 - 103
UC 612.017:617.715-002
IMMUNE SYSTEM DISORDERS IN PATIENTS WITH SCLERITIS
Jasmina Djordjević-Jocić, Gordana Zlatanović, Gordana Stanković-Babić
Ophthalmology Clinic, Clinical Centre, Niš, Serbia
E-mail: nimiti@EUnet.yu
Summary. A large number of abnormalities is present in the immune system of the patients suffering from scleritis of unknown etiology as well as from scleritis associated with other systemic diseases. The aim of the present work was to investigate the level immune parametars in serum patients ( imminoglobin IgG, IgA, IgM, complement-C3, circulating immune complexes - CIC, rheumatoid factor - RF, antinuclear antibodies - ANA) with scleritis and/or associated systemic mediate disease. The first group included 30 patients with scleritis of unknown etiology, the second group included 30 patients with systemic diseases without ocular changes and the third one consisted of 30 patients with scleritis associated with other systemic diseases of connective tissue. Increased IgG was found in 33.3% of the patients in group I and in 66.7% of the patients in groups II and III, with p<0.05. Increased IgM values were found in 13.3% of the patients in group I, 33.3% of the patients in group II and in 53.3% of the patients in group III, showing again statistically significant difference in relation to the control group. Increased serum CIC values were found in 26.7% of the patients in group I, in 46.7% of the patients in group II and in 60% of the total number of subjects in group III; there is statistically significant difference in favour of group with scleritis with associated diseases. Statistically significant negative correlation between serum CIC levels and complement C3 component in the investigated groups was found in the work. No significant difference between CIC levels and RF presence was found in group I, while statistically significant correlation between CIC levels and RF presence was found in group III of the subjects.
Key words: Scleritis, circulating immune complexes, complement, rheumatoid factor, antinuclear antibody
POREMEĆAJ IMUNSKOG SISTEMA KOD SKLERITISA
Kratak sadržaj: U imunskom sistemu bolesnika sa skleritisom kako nepoznate etiologije, tako i sa pridruženim sistemskim bolestima prisutne su brojne abnormalnosti. Cilj rada je bio da ispitamo nivo imunskih parametara u serumu bolesnika (imunoglobulini klase IgG, IgM, IgA, komlementa-C3, cirkulišući imuni kompleksi - CIC, reumatoidni fakor-RF i antinuklearna antitela-ANA) koji su imali skleritis sa ili bez pridruženog sistemskog oboljenja. Prva grupa je imala 30 bolesnika sa skleritisom nepoznate etiologije, II grupa je imala 30 bolesnika sa sistemskim bolestima bez promena na očima, III- grupu su činili 30 bolesnika koji su imali skleritis udružen sa sistemskim bolestima vezivnog tkiva. U I grupi povišene vrednosti IgG imalo je 33,3% bolesnika, dok je u II i III grupi 66,7% bolesnika i ovde je p < 0,05. Povišene vrednosti IgM je u I grupi imalo 13,3% bolesnika u II grupi 33,3%, dok je u III grupi 53,3% bolesnika: i ovde postiji statistički značajna razlika u odnosu na kontrolnu grupu. Povišene vrednosti CIC u serumu je u I grupi imalo 26,7% ispitanika, u II grupi 46,7%, dok je u III grupi njih 60% od ukupnog broja ispitanika; postoji statistički značajna razlika u korist grupe sa skleritisom sa pridruženim bolestima. U našem radu smo pronašli statisički značajnu negativnu korelaciju između nivoa CIC u serumu i C3 komponente komplementa u ispitanim grupama. U I grupi nema značajne razlike između nivoa CIC i prisustva RF, dok u III grupi ispitanika postoji statistička značajna povezanost između nivoa CIC i prisustva RF.
Ključne reči:   skleritis, cirkulišući imuni kompleksi, koplement, reumatoidni faktor, antinuklearna antitela