Vol.13, No 2, 2006 pp. 94 - 97
UC 615.22.03(497.11)
THE USE OF CARDIOVASCULAR DRUGS IN NIŠ
REGION OF SERBIA
Radmila M. Veličković-Radovanović1,
Slobodan M. Janković2, Marina Z. Avramović1,
Svetislav Kostić1
1Institute of Nephrology and Hemodialysis, Department
of Clinical Pharmacology, Clinical Centre, Niš, Serbia
2Centre for Clinical & Experimental Pharmacology, Clinical
Centre, Kragujevac, Serbia
E-mail: farmakoterapija@yahoo.com
Summary. Cardiovascular disease mortality is high in Serbia. Analysis
of cardiovascular drugs utilization in the population is the basis for
the assessment of cardiovascular pharmacotherapy appropriateness. The aim
of this study was to analyze the out-of-hospital cardiovascular drug utilization
in the Niš region of Serbia & Montenegro. Using the ATC/DDD methodology,
we analyzed the utilization of cardiovascular drugs dispensed on prescription
in the Niš region in years 2003 and 2004. The study was retrospective,
based on data obtained from Central City Pharmacy Niš, and results were
expressed in DDDs/1000 inhabitants/day. The most frequently prescribed
drug in 2003 and 2004 was enalapril (31.16 and 41.71DDDs/1000 inhabitants/day,
respectively). The consumption of other ACE inhibitors was much less (7.36
and 10.83 DDDs/1000 inhabitants/ day, respectively). The next most commonly
used drugs were a selective beta blocker and a ACE inhibitor (atenolol-8.49
DDDs/1000 inhabitants/day; cilazapril 6.48 DDDs/1000 inhabitants/day in
2003). The use of amlodipine significantly increased in 2004 (from 6.41
in 2003 to 10.21 DDDs/1000 inhabitants/day in 2004), while that of nifedipine
decreased (from 4.45 in 2003 to 3.82 DDDs/1000 inhabitants/day in 2004).
Marginal use of diuretics was noted (4.4 DDDs/1000 inhabitants/day in 2003,
and 5.5 DDDs/1000 inhabitants/day in 2004). This analysis pointed to significant
therapeutical irrationalities in the Niš region, which could be overcome
by targeted education of the prescription-givers.
Key words: Utilization of drugs,
cardiovascular system, defined daily dose
UPOTREBA KARDIOVASKULARNIH LEKOVA U NIŠKOM
REGIONU
Kratak sadržaj: Analiza upotrebe kardiovaskularnih lekova u populaciji
čini osnovu za procenu racionalnosti kardiovaskularne farmakoterapije.
Radi uporedjivanja sa drugim populacijama, upotreba lekova se izražava
kao broj definisanih dnevnih doza (DDD) na 1000 bolesničkih dana, ako se
radi o populaciji hospitalizovanih bolesnika ili na 1000 stanovnika
na dan, ako se radi o opštoj populaciji. Cilj ove studije bio je da analizira
vanbolničku upotrebu kardiovaskularnih lekova u regionu Niša. Koristeći
ATC/DDD metodologiju, analizirali smo upotrebu kardiovaskularnih lekova
na osnovu broja propisanih recepata u niškom regionu, u 2003 i 2004 godin.
Retrospektivna analiza je bazirana na podacima dobijenim iz Centralne gradske
apotekarske ustanove. Rezultati su prikazani brojem DDD/1000 stanovnika/dan.
Najčešće propisivani lek u 2003. i 2004. bio je Enalapril (31,16 : 41,71
DDD/1000 stanovnika/dan). Najviše korišćeni beta blokator je bio Atenolol
(8,49 DDD/1000 stanovnika/dan). ACE inhibitor Cilazapril se nalazi na trećem
mestu po broju propisanih recepata u 2003g (6,48 DDD/1000 stanovnika/dan).
Upotreba Amlodipina značajno je povećana u 2004. (6,41 : 10,21 DDD/1000
stanovnika /dan), a Nefedipina smanjena (4,4 : 3,82 DDD/1000 stanovnika/dan).
Zabeleženo je marginalno korišćenje diuretika (4,4 : 5,5 DDD/1000 stanovnika/dan),
statina i drugih ACE inhibitora, osim Enalaprila i Cilazaprila. Ova analiza
je pokazala značajne terapijske iracionalnosti u farmakoterapiji
kardiovaskularnih oboljenja, koje se mogu prevazići odgovarajućom
edukacijom.
Ključne reči: Upotreba
lekova, kardiovaskularna oboljenja, definisana dnevna doza
