Vol.13, No 2, 2006 pp. 70 - 73
UC 616.361-006.6:612.017
COMBINED EVALUATION OF CYCLIN E AND P53
EXPRESSION
IN GALLBLADDER CANCER
Alsheyab Fawzi , Morouge Ziada
Jordan University of Science and Technology, Dept. of Biotechnology
& Genetic Engineering
E-mail: fawzish@just.edu.jo
Summary. This study was to investigate the role of Cyclin E and
p53 as a useful prognostic indicators in cancerous process of gallbladder
carcinomas, and to correlate the expression of these factors with clinicopathological
parameters: age, sex, stage, invasion and grade. Thirty two gallbladder
carcinomas specimens were surgically resected and were examined immunohistochemically.
All patients were diagnosed histopathologically according to the criteria
of pathology department. Levels of cyclin E and p53 were found as 34.4%
and 65.5% among the patients respectively. Frequencies for p53 expression
were high, which suggests that p53 may play an important role in GBC.
Key words: Cyclin E, p53, immunohistochemistry,
gallbladder cancer
KOMBINOVANA EVALUACIJA CIKLINA E I P53
KOD KANCERA ŽUČNE KESE
Kratak sadržaj: Ova studija je proučavala utical ciklina E i p53
kao korisnih prognostičkih indikatora kod kancera žučne kese i ekspresiju
ova dva faktora u korelaciji sa kliničkopatološkim parametrima: starost,
pol, stanje, invazija i stepen. Trideset dva uzorka karcinoma žučne kese
su ispitivana imunohitohemijski posle resekcije. Svi pacijenti su histopatološki
dijagnostifikovani prema kriterijumu patološkog odeljenja. Nivoi ciklina
E i p53 su nađeni u 34,4% i 65,5% pacijenata. Učestalost ekspresije p53
je visoka, što sugeriše da p53 može da ima važnu ulogu u karcinomu
žučne kese.
Ključne reči: ciklin E, p53,
imunohistohemija, kancer žučne kese
