Vol.13, No 2, 2006 pp. 70 - 73
UC 616.361-006.6:612.017

COMBINED EVALUATION OF CYCLIN E AND P53 EXPRESSION
IN GALLBLADDER CANCER
Alsheyab Fawzi , Morouge Ziada
Jordan University of Science and Technology, Dept. of Biotechnology & Genetic Engineering
 E-mail: fawzish@just.edu.jo

Summary. This study was to investigate the role of Cyclin E and p53 as a useful prognostic indicators in cancerous process of gallbladder carcinomas, and to correlate the expression of these factors with clinicopathological parameters: age, sex, stage, invasion and grade. Thirty two gallbladder carcinomas specimens were surgically resected and were examined immunohistochemically. All patients were diagnosed histopathologically according to the criteria of pathology department. Levels of cyclin E and p53 were found as 34.4% and 65.5% among the patients respectively. Frequencies for p53 expression were high, which suggests that p53 may play an important role in GBC.
Key words: Cyclin E, p53, immunohistochemistry, gallbladder cancer

KOMBINOVANA EVALUACIJA CIKLINA E I P53
KOD KANCERA ŽUČNE KESE
Kratak sadržaj: Ova studija je proučavala utical ciklina E i p53 kao korisnih prognostičkih indikatora kod kancera žučne kese i ekspresiju ova dva faktora u korelaciji sa kliničkopatološkim parametrima: starost, pol, stanje, invazija i stepen. Trideset dva uzorka karcinoma žučne kese su ispitivana imunohitohemijski posle resekcije. Svi pacijenti su histopatološki dijagnostifikovani prema kriterijumu patološkog odeljenja. Nivoi ciklina E i p53 su nađeni u 34,4% i 65,5% pacijenata. Učestalost ekspresije p53 je visoka, što sugeriše da p53 može da  ima važnu ulogu u karcinomu žučne kese.
Ključne reči: ciklin E, p53, imunohistohemija, kancer žučne kese