Vol.13, No 1, 2006 pp. 6 - 10
UC 613.83:612.35
THE
ELECTRON-MICROSCOPIC FINDINGS ON THE LIVER
IN CHRONIC ABUSE OF HEROIN
Goran Ilić, Lidija Kostić-Banović, Radovan Karadžić,
Jovan Stojanović
Institute for Forensic Medicine,
Faculty of Medicine, University of Niš, Serbia and Montenegro
Summary. The study included an analysis of 60 autopsies, 50 of
which were from the group of intravenous heroin addicts, and 10 served
as controls (corpses of young and healthy people who died of mechanical
traumas that did not affect the liver). The ultrastructural research
has a decisive role in gathering new facts about the liver's response
to different drugs. Various changes occur on organelles, plasma
membrane of hepatocytes and biliar channels, as well as on the nucleus.
The most important ultrastructural findings include: hyperplasia and
hypertrophy of the smooth endoplasmic reticulum (SER), which is
histologically a vesicular degeneration of hepatocyte developed as a
result of the increased synthesis of enzymes of SER due to chronic i.v.
heroin intake, and the presence of continuous basal membrane followed
by conversion of the sinusoids into capillaries (in cases of chronic
active hepatitis and cirrhosis) which leads to a disorder of
microcirculation and further progress of cirrhosis.
Key words: Intravenous heroin
intake, ultrastructural liver lesions
ELEKTROMIKROSKOPSKI NALAZI JETRE
KOD HRONIČNE ZLOUPOTREBE HEROINA
Kratak sadržaj: Studija obuhvata analizu 60 autopsija i to 50 iz
grupe intravenskih heroinomana, a 10 obdukcija je predstavljalo
kontrolnu grupu (leševi mladih i zdravih osoba smrtno stradalih zbog
mehaničkih trauma koje nisu zahvatile jetru). Ultrastrukturna
istraživanja imaju odlučujuću ulogu u dobijanju novih podataka o
odgovoru jetre na različite droge. Različite promene se odvijaju na
organelama, na citoplazmatskoj membrane hepatocita i žučnih kanalića,
kao i na jedru. Najznačajniji ultrastrukturni nalazi su: hiperplazija i
hipertrofija glatkog endoplazmatskog retikuluma, koja se histološki
sagledava kao vezikulatna degeneracija hepatocita, nastala kao
posledica povećane sinteze enzima endoplazmatskog retikuluma zbog
hroničnog intravenskog unošenja heroina i postojanje kontinualne
bazalne membrane uz konverziju sinusoida u kapilare (u slučajevima sa
hroničnim aktivnim hepatitisom i cirozom), što uzrokuje poremećaj
mikrocirkulacije i dalju progresiju ciroze.
Ključne reči: Intravensko
unošenje heroina, ultrastrukturna oštećenja jetre
