Vol. 10, No 2, 2003 pp. 92-94
UC 616-092.9:612.1:615.31
INFLUENCE OF INTRACEREBROVENTRICULAR INJECTED
6-OHDA
ON CARDIOVASCULAR EFFECTS OF ACETYLCHOLINE,
PILOCARPINE AND NICOTINE
Slavimir Veljković, Mirjana Radenković, Nenad Stojiljković,
Suzana Branković, Milena Veljković, Dragana Veličković
Department of Physiology, Medical School, Niš, Serbia
Summary. The influence of catecholamine synthesis inhibitor, 6-OHDA
on cardiovascular effects of intracerebroven-tricularly (i.c.v.) injected
acetylcholine, pilocarpine and nicotine was investigated in anaesthetized
cats. Acetylcholine, pilocarpine and nicotine administered i.c.v. caused
a dose-dependent decrease of blood pressure. In animals previously treated
with inhibitor synthesis of catecholamine, 6-OHDA, a statistically significant
fall or abolition of hypotensive effects acetylcholine, pilocarpine and
nicotine were obtained. Based on these results the authors suggest that
the intact central catecholaminergic neuron is needed for nicotinic and
muscarinic receptors in the central regulation of arterial blood pressure.
Key words: Hypotensive activity, acetylcholine, pilocarpine,
nicotine, 6-hydroxidopamine
UTICAJ INTRACEREBROVENTRIKULARNO UBRIZGANOG
6-OHDA
NA KARDIOVASKULARNE EFEKTE ACETIL HOLINA,
PILOKARPINA I NIKOTINA
Kratak sadržaj: Praćen je uticaj inhibitora sinteze kateholamina,
6-OH DA na kardiovaskularne efekte intracerebroventrikularno ubrizganih
acetilholina, pilokarpina i nikotina. Intracerebroventrikularno ubrizgani
acetilholin, pilokarpin i nikotin, izazvali su dozno zavisno sniženje krvnog
pritiska. U životinja prethodno tretiranih inhibitorom sinteze kateholamina,
6-OHDA registrovan je statistički značajno manji (do odsutni) hipotenzivni
efekat acetilholina, pilokarpina i nikotina. Na osnovu dobijenih rezultata
autori zaključuju da se kardiovaskularni efekti izazvani centralnom stimulacijom
nikotinskih i muskarinskih receptora ostvaruju uz učešće intaktnog kateholaminergičkog
neurona.
Ključne reči: Hipotenzivno dejstvo, acetilholin, pilokarpin,
nikotin, 6-hidroksidopamin
