Vol. 10, No 2, 2003 pp. 88-91
UC 616-092.9:612.017]:611.813
NERVE GROWTH FACTOR AND FIBROBLAST GROWTH
FACTOR PREVENTS ACUTE QA-EXCITOTOXICITY IN RAT BASAL FOREBRAIN
Ivana Vasiljević1, Marina Jovanović1,
Rosa Mihajlović2, Dejan Mićić3,
Miodrag Čolić1, Milica Ninković1,
Živorad Maličević1
1Military Medical Academy - Institute
for Medical Research, 2Institute for rehabilitation,
3School of Medicine, Belgrade
E-mail: ivanav13@yahoo.ca
Summary. Adult Wistar rats were treated with unilateral intrastriatal
injection of quinolinic acid (QA) in one single dose of 150 nM/L. The other
two group of animals were pretreated with nerve growth factor (NGF) and
fibroblast growth factor (FGF), respectively. Control group was treated
with 0.154 mmol/L saline solution likewise. Activity of cytochrome c oxidase
(COX) was decreased in the basal forebrain of neurotrophins (NTF)-treated
animals. Striatal lesions led to the loss of tonic inhibitory inputs to
the globus pallidus with consequent increase changes due to transsynaptic
degeneration in the basal forebrain, will be also less extensive in the
NTF-treated animals.
Key words: Huntington disease, quinolinic acid, nerve growth
factor, fibroblast growth factor, basal forebrain, cytochrom c oxidase
NERVNI I FIBROBLASTNI FAKTOR RASTA SPREČAVAJU
AKUTNU EKSCITOTOKSIČNOST IZAZVANU HINOLINSKOM
KISELINOM
U BAZALNOM PREDNJEM MOZGU PACOVA
Kratak sadržaj: Adultni Wistar pacovi su jednostrano dobili intrastrijatnu
injekciju hinolinske kiseline (HK) u pojedinačnoj dozi od 150 nM/L. Druge
dve grupe životinja su pre neurotoksina tretirane nervnim (NGF), odnosno
fibroblastnim faktorom rasta (FGF). Kontrolna grupa je dobijala 0,154 mmol/L
fiziološki rastvor na isti način. Aktivnost citohrom c oxidase (COX) je
snižena u bazalnom prednjem mozgu kod životinja tretiranih neurotrofinima.
Oštećenja strijatuma koja vode u gubitak toničnih inhibitornih aferenci
u globus palidus sa konsekventnim povećanjem promena, a povezane su sa
međusinaptičkom degeneracijom u bazalnom prednjem mozgu, biće manje izražene
kod životinja tretiranih neurotrofinima.
Ključne reči: Hantingtonova bolest, hinolinska kiselina, nervni
faktor rasta, fibroblastni faktor rasta, bazalni prednji mozak, citohrom
c oksidaza
