Vol. 9, No 3, 2002 pp. 217 - 222
UC 618.1:616-002.828]:616-036.87
RECURRENT GENITAL CANDIDOSIS OF WOMEN:
CONSEQUENCE OF REINFECTION OR RELAPSE
Suzana Tasić1, Nataša Tasić1,
Aleksandar Tasić2, Sanja Mitrović3
11Institute of Microbiology and Immunology,
Faculty of Medicine, Niš
2Public Health Institute Niš, Serbia
3Institute of Microbiology and Immunology,
Faculty of Medicine, Beograd, Serbia
Summary. A most interesting fact for scientific investigations is
that 5% of women are afflicted with recurrent genital candidosis (RGC)
characterized by three or more genital, fungal infection episodes per a
year. The data analysis is also interesting because it reveals that the
most significant risk factors such as pregnancy, diabetes mellitus, long
term use of antibiotics and citostatics, hormonal therapy and idiopathic
or acquired immunodeficient conditions have not been verified.
There are many different hypotheses about RGC pathogenesis, but two
of them have set the course for further research. The first maintains that
antimycotic therapy leads to eradication of Candida fungi from vaginal
mucosa and that the recurrent episodes of genital candidosis are caused
by re-infection. The second hypothesis has an absolutely opposite starting
ground. According to this theory, the frequent RGC episodes have been caused
by a failure to eradicate Candida sp. from female genital tract. According
to this theory, RGC is not caused by re-infection, but by relapse.
Key words: Recurrent genital candidosis, reinfection,
relapse
REKURENTNA GENITALNA KANDIDOZA ŽENA:
POSLEDICA REINFEKCIJE ILI RECIDIVA
Kratak sadržaj: Podaci iz referentne literature ukazuju da 5% žena
boluje od rekurentne genitalne kandidoze (RGK), bolesti koju karakteriše
tri ili više epizoda gljivične genitalne infekcije u toku godine. Zanimljivost
ove statističke realnosti je u tome da kod ovih žena najznačajniji faktori
rizika kao što su trudnoća, diaebetes mellitus, dugotrajna upotreba antibiotika,
citostatika, hormonske terapije, idiopatska i stečena imunodeficijentna
stanja ostaju neverifikovani.
Postoji znatan broj raznorodnih hipoteza o patogenezi RGK, ali su dve
hipoteze uslovile glavne tokove istraživanja.
Jedna teorija zastupa stav da terapija antimikoticima sprovodi eradikaciju
gljiva roda Candida sa vaginalne mukoze i da je ponovljena epizoda genitalne
kandidoze posledica reinfekcije.
Druga hipoteza ima za osnovu dijametralno suprotnu pretpostavku. Po
ovoj teoriji česte epizode RGK posledica su neeradikacije Candida sp. iz
genitalnog trakta žene, odnosno posledica su recidiva.
Ključne reči: Rekurentna genitalna kandidoza, reinfekcija, recidiv
