Vol. 9, No 1, 2002 pp. 114 - 118
UC 616.61-004 616.613-006 616.617-006
UPPER UROTHELIAL TUMORS AND BALKAN NEPHROPATHY-
DOSE RESPONSIBLE DISEASES
Jovan Nikolić1, Milan Djokić1,
Dragan Crnomarković1, Jelena Marinković2
1Urologic Clinic, Faculty of Medicine
Belgrade, Serbia
2Institute of Social Medicine, Statistics
and Health Research, Faculty of Medicine, Belgrade, Serbia
E-mail: milly@yubc.net
Summary. In the period 1963-1998, 1033 patients were operated from
upper urothelial tumors (UUT). They lived in the region of 808 settlements
(1.162.225 inhabitants). Tumors were not registered at 524 villages (243,
263 inhabitants). Patients from 16 towns (182 pts./ 452,600 inhabitants)
are not included in this analysis. The remaining 268 villages (851 pts.
/ 466,362 inhabitants) are, according to their UUT incidence rates, classified
into 10 groups, numbered from 0 to 9 as shown on the enclosed map.
The average age of UUT patients is in inverse proportion to the incidence
in the villages.
The number of villages (within brackets) and the average annual incidence
of UUT per 100, 000 inhabitants in various incidence groups are: (9) 44.16;
(22) 19.52; (25) 11.8; (25) 8.36; (26) 6.40); (22) 5.09;(21) 4.40; (10)
3.83; (10) 3,37; (98) 1.10.
The number of patients (within brackets) and the average age in the
same groups are (124) 60.64 yrs.; (159) 62.36 yrs.; (127) 63.20 yrs.; (103)
64.17 yrs.; (62) 64.97 yrs.; (62) 66.03 yrs; (47) 64.13 yrs; (13) 59.3
yrs; (12) 65.33 yrs; (142) 62.39 yrs. The difference of average age among
different incidence groups tested by "one way" ANOVA are significant
(F = 2.408; p = 0.011).
The correlation of incidence with the average age of patients is suggestive
of a dose responsible disease.
Key words: Upper urothelial tumors, incidence - age depandance,
Balkan endemic nephropathy
