FACTA UNIVERSITATIS

Vol. 8, No 1, 2001 pp. 11 - 18
UC 612.17; 611.12

THE ADVANTAGES OF CARVEDILOL IN CORONARY ARTERY DISEASE
Svetlana Apostolović¹, Milan Pavlović¹, Miloje Tomašević¹, Aleksandar Stojković¹, Ružica Janković¹, Slobodan Ilić²
¹Clinic for Cardiology, Clinical Center, Niš, Yugoslavia, ²Society for Liason Psychiatry, Niš, Yugoslavia
e-mail: sapos@eunet.yu

Summary. Dilatrend (carvedilol) is a nonselective beta and alpha blocker with antioxidation and antiprolipherative effects. These effects prevent mechanical damage of the endothelium of coronary arteries and have no negative influ-ence on metabolic risk factors: lipid prophyl and insulin resistence. With beta-blockade, dilatrend (carvedilol) reduces the heart rate and blood pressure, with alpha-blockade it reduces the peripheral vascular resistence and in that way decreases the myocardial oxygen consumption and myocardial wall stress. Dilatrend (carvedilol) prolonges exercise limits (duration of exercise). Applied in the acute phase of myocardial infarction, dilatrend (carvedilol) increases the patients' survival rate, reduces new coronary events, and with antioxydation action it prevents reperfusion arrhyth-mias. With positive hymodinamic effects it improves the left ventricle function in patients with ischemic cardiomyopa-thy, and gives a chance for survival to the coronary patients who run high surgery risk.
Key words: Carvedilol, coronary disease, myocardial infarction

PREDNOSTI KARVEDILOLA U KORONARNOJ BOLESTI Kratak sadržaj: Dilatrend (karvedilol) je neselektivni beta i alfa blokator sa antioksidativnim i antiproliferativnim dejstvom. Pomenutim efektima prevenira mehaničko oštećenje endotela koronarnog krvnog suda, i ujedno ne utiče nepovoljno na metaboličke faktore rizika: lipidni profil i insulinsku rezistenciju. Beta blokadom redukuje srčanu frekvencu i krvni pritisak, alfa-blokadom redukuje perifernu vaskularnu rezistenciju što ima za rezultat smanjenje miokardne potrošnje kiseonika i miokardnog zidnog stresa. Dilatrend (karvedilol) podiže prag za naporom indukovanu ishemiju. Primenjen u akutnoj fazi infarkta miokarda, dilatrend (karvedilol) popravlja preživljavanje bolesnika, redukuje nove koronarne događaje, dok antioksidativnim svojstvima sprečava reperfuzione poremećaje ritma. Povoljnim hemodinamskim efektima popravlja funkciju leve komore bolesnika sa ishemičnom kardiomiopatijom, i daje šansu za preživljavanje bolesnicima sa visokim operativnim rizikom.
Ključne reči: Karvedilol, koronarna bolest, infarkt miokarda