Vol. 8, No 1, 2001 pp. 6 - 10
UC 616.23
THE ROLE OF EOSINOPHILS IN ASTHMA
Miloš Filipović 1, Snežana Cekić 2
1 Institute of Pulmonary diseases Niš
2 Institute of Physiology, University School of Medicine,
Niš, Yugoslavia
e-mail: milosfilip@yahoo.com
Summary. Asthma is a common respiratory disease. The prevalence
of asthma has been increasing over the past twenty years in most countries,
and it affects up to 10% of the population of developed countries. Airway
inflammation is a major factor in the pathogenesis of asthma. The presence
of peripheral blood eosinophilia and activated eosino-phils in the chronic
inflammatory infiltrate of the airways is a characteristic of both allergic
and non-allergic asthma. This review article describes the mechanisms of
eosinophillic inflammation in asthma: eosinophilopoiesis, role of eo-sinophil
growth factors (IL-3, IL-5 and GM-CSF), phases in the recruitment of eosinophils
from bone marrow to air-way mucosa, activation and eosinophil effector
functions in the pathogenesis of asthma.
Key words: Eosinophils, asthma, inflammation, cytokines, chemokines
ULOGA EOZINOFILA U ASTMI
Kratak sadržaj: Astma je česta respiratorna bolest. Tokom poslednjih
dvadeset godina u većini zemalja prevalencija astme beleži porast, i zahvata
do 10% stanovništva u razvijenim zemljama. Zapalenje disajnih puteva je
glavni faktor u patogenezi astme. Prisustvo eozinofilije periferne krvi
i aktivisanih eozinofila u hroničnom zapalenjskom infiltratu disajnih puteva,
je karakteristično i za alergijski i nealergijski oblik astme. Ovaj pregledni
članak opisuje mehanizme eozinofilne inflamacije u astmi: eozinofilopoiezu,
ulogu faktora rasta eozinofila (IL-3, IL-5 and GM-CSF), faze u prelasku
eozinofila iz kostne srži do sluzokože disajnih puteva, aktivaciju i efektorske
funkcije eozinofila u patogenezi astme.
Ključne reči: Eozinofili, astma, zapalenje, citokini, hemokini
